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物理学院“博约学术论坛”系列报告(第129期)

发布日期:2017年10月23日
题目:3D Imaging of A Single Molecule

报告人:任罡教授(美国加州大学伯克利Lawrence实验室)

时间:2017年10月25日(周三)上午10:00

地点:新葡萄京娱乐场8455中心教学楼610

Abstract:Structural study on flexible, dynamic and heterogeneous macromolecules is challenging by current techniques, including X-ray crystallography, nuclear magnetic resonance (NMR) spectrum, cryo-electron microscopy (cryo-EM) single-particle reconstruction, due to requirement of averaging the signals from thousands to millions of different macromolecules that are assumed sharing a single structure. We reported an approach to determine the 3D structure of a single-instance macromolecule at near a nanometer resolution, termed individual-particle electron tomography (IPET). IPET does not require a pre-given initial model, averaging of multiple molecules or an extended ordered lattice, but can achieve a 3D structure at near nanometer resolution from heterogeneous sample via structure determination of each individual macromolecule. The comparison of these macromolecule structures provides an experimental opportunity to reveal macromolecular dynamics, equilibrium fluctuation, mechanism and even catching the intermediate-state 3D structure during chemical reaction.

Education

Lanzhou University, China, B.S. 06/1990, Theoretical Physics

Lanzhou University, China, M.S. 06/1993, Theoretical Physics

Univ. of Science and Technology Beijing, China, Ph.D. 06/1997, Material Physics

The Scripps Research Institute, La Jolla, CA, USA

Postdoctoral, 06/1997-01/2004, Cell Biology (Cryo-Electron Microscopy)

Positions and Employment

1999-2001 American Heart Association Postdoctoral Fellow, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA

2001-2004 University of California AIDS Research Postdoctoral Fellow, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA

2004-2006 Staff Scientist (Non-PI), The National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX

2006-2010 Keck Fellow (Principal Investigator), Department of Biochemistry and Biophysics, University of California, San Francisco, CA

2010-2015 Career-track Staff Scientist (Principal Investigator), The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA

2015- Career Staff Scientist (Principal Investigator), The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA

联系方式:物理学院办公室(68913163)

邀请人:赵清教授网址:/

 

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